On Friday night in Winston-Salem’s West End, developer John Bryan bellies up to the bar at Hoots and gets himself a Wild Turkey on the rocks. Why not? It’s been a long day at the West End Mill Works, his current project, and there’s more like it to come.

He’s in the same clothes he’s been wearing all day: work jeans and flannel. Combined with his autumn beard and trucker cap, it gives him the outward appearance of a carpenter, which is in fact how he once made his living.

He’s still handy with a hammer and nails — he spent the day erecting the monthly village that is Hoots Flea Market with his partner in the venture, Joe Bradford, and they’ll be out there first thing in the morning to hang banners and put the finishing touches on the pumpkin patch, the balloon dartboard, the stage and the sound system.

The flea market is just the latest bough on Bryan’s entrepreneurial tree that goes back more than a decade, laying roots throughout Winston-Salem’s most cultured corners.

Hoots Flea Market was conceived, planned and given the green light during a single 20-minute conversation in the parking lot of Krankies Coffee, another pearl in Bryan’s string of influence. It was up and running within a month.

Krankies took a bit longer to flesh out.

The space at the corner of East Third Street and Patterson Avenue known as Krankies began its life as a meatpacking facility and then, along with a lot of the rest of that industrial neighborhood, went fallow.

In the mid-1990s, a group of young men got their hands on the building — the technical term for what they did may be “squatting” — dubbed it the “Werehouse” and began using the space for art and music.

This was a very different time for downtown Winston-Salem, before the Arts District had evolved and the restaurant row on West Fourth Street came of age. There was no Foothill’s Brewing, no Finnegan’s Wake or Silver Moon Saloon. Ziggy’s was still over on Baity Street, and the Garage was just a gleam in Richard Emmett’s eye. Allen Joines was still city manager; he wouldn’t become mayor until 2001.

The area around the Werehouse was industrial gothic, uninhabited, sketchy. It was possible in those days for these rock shows and art openings to escape official notice.

It was a half-assed political stunt that put them on the official radar, and that’s what John Bryan wants to talk about tonight.

When the W. Dennie Spry Soccer Stadium opened on the Wake Forest University Campus in 1996, Bryan and the crew from the Werehouse dressed as monsters and mounted a protest, the intent of which is unclear.

By 1997 the bohemian crew had bought the building — it sold for $60,000, with a tax value today of $312,500 — which began attracting a series of visits from the police department and fire marshall after the monster mash. It could have been the end for this vanguard of the cultural movement in the City of Arts and Innovation. Winston-Salem would be a very different place today had the Werehouse been shut down.

For advice, Bryan called on city council member Wanda Merschel — he knew her because he made her cabinets. He says she was able to help get the fire department off his back.

And he found another powerful ally in one of the city’s favorite sons.

Phil Hanes was a philanthropist and patron of the arts who spent the last three decades of his life crafting Winston-Salem’s reputation as the City of the Arts.

Hanes helped start the Southeastern Center for Contemporary Art and the Piedmont Opera in the 1950s, when he was still president of the Hanes Finishing & Dye Co., the family business. In 1997 he gave $1 million to the UNC School of the Arts, which he had helped found 50 years ago, and another million in 2000. He was the man behind the Stevens Center and joined the city’s Arts Council, the first in the country, a year after it was created. His reputation extended beyond the borders of the city to state and national arts groups. When Hanes died in 2011, his ashes were left inside a piece of public art created specifically for that purpose.

But he was alive and well back then at the turn of the century, and Bryan thought Hanes might understand the movement he was trying to foment.

“Someone said I should meet him,” Bryan says, leaning over the bar. “I just went to his office and knocked on his door.”

At his audience with Hanes, Bryan explained what he and his mates were trying to do with their space — live music and art, culture emanating from a forgotten district, the development of human capital. He couldn’t get a read on the guy.

“He didn’t say much,” Bryan remembers, “but he got to work.”

Hanes took a shine to the Werehouse crew and made some calls on their behalf. The Werehouse eventually morphed into PS 211, a nonprofit with backing from the Arts Council and SECCA. That, Bryan says, was Hanes’ doing.

“[Hanes] would go to boardrooms and official meetings and say, ‘These kids are the future of the city. You need to pay attention to them and you need to help them,’” Brian says. “He got it.”

And with that he finishes his bourbon, pays his tab and heads out the door. Gonna be an early day tomorrow.

PS 211 really became Krankies when they purchased the roasting operation of Maria Braught, one of the city’s first foodies of the modern era, on a handshake deal in her kitchen.

They needed something to sell with the coffee, so Cary Clifford set up shop in the basement in an effort that would eventually become Camino Bakery, today a Fourth Street landmark.

A farmers market began holding court in the parking lot on Tuesdays, and the Cobblestone Farmers Market was born.

Now the retail spots along Patterson are full. Reanimator, a record and curio shop, came on last year. There’s also a store that sells clothes for dogs.

In 2009, Bryan and his partners in Krankies moved into the Arts District with Single Brothers, a barroom smaller than a garage where Eric Swaim cut his teeth as a bartender before opening Hoots Roller Bar almost exactly a year ago and beginning brewing operations in the West End Mill Works.

Besides Hoots, the Mill Works houses the Breathing Room, a holistic healing space; Sutler’s Spirit Co., which will be putting out its first bottles of gin this winter; Eight Points Muay Thai & Fitness boxing gym; the Porch Restaurant & Cantina; and the Olio, an open glass-blowing studio.

Bryan says he “curates his tenants,” looking to create entrepreneurial cultures that, like Krankies, galvanize existing community networks into successful businesses.

“It’s development from the standpoint that the community is developing it,” Bryan says. “We’ve got layers of support, and not all of it is financial.”

It’s Friday morning, hours before he has his nightcap at Hoots, and he’s taking a break in the shade by the creek that flows through the property at the West End Mill Works, one of the few moving waterways in the city, he points out.

The property is significant because it links three disparate neighborhoods — the affluent Buena Vista, funky West End and Thurmond, a working-class African-American neighborhood.

“The stuff that ‘gets on the radar,’ gets attention from banks, that’s the stuff everybody has,” Bryan says. “That’s your Walgreen’s, your McDonald’s. Every city has those.”

Bryan’s tenants share a few common traits: They’re all local and one of a kind; they’re all run and staffed by people deeply committed to the enterprises; and they all gain immediate acceptance by Winston-Salem’s culturati — the people who actually go out and do stuff.

And it’s not gone unnoticed.